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Friday, January 13, 2006

A Comparison of Intrathecal Plain Solutions Containing Ropivacaine 20 or 15 mg Versus Bupivacaine 10 mg
Helena Kallio, MD PhD, Eljas-Veli T. Snäll, MD, Markku P. Kero, MD, and Per H. Rosenberg, MD PhD
Ropivacaine, which blocks sensory nerve fibers more readily than motor fibers, is considered to be less potent than bupivacaine.
Our hypothesis was that, when used in spinal anesthesia for day surgery, ropivacaine 15 and 20 mg would provide faster motor recovery than bupivacaine 10 mg.
This prospective, randomized, double-blinded study included 90 ambulatory lower-extremity surgery patients who received 2 mL of ropivacaine 1%, ropivacaine 0.75%, or bupivacaine 0.5%. Motor block was tested with the Bromage scale, and sensory block was tested with pinprick.
Ropivacaine 15 mg provided faster recovery of motor block than did bupivacaine 10 mg , but the median duration of sensory block at T10 did not differ significantly from that with bupivacaine 10 mg . The median duration of sensory block at T10 was significantly longer with ropivacaine 20 mg than with bupivacaine 10 mg , but the median recovery from motor block did not differ significantly.
This study conclude that the duration of sensory block of ropivacaine was two thirds and the duration of motor block was half when compared with bupivacaine, with calculations based on the duration-per-milligram of the local anesthetic.
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Anesth Analg 2004;99:713-717

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